Our Regina Campus opened in 1976 when the Saskatchewan Indian Federated College and the University of Regina signed a federated agreement.

On June 21, 2003, when the Saskatchewan Indian Federated College officially changed its name to the First Nations University of Canada, the Regina Campus officially opened the doors of its new building. This new building houses executive, administrative and academic departments formerly situated on the University of Regina campus and around Regina.

Regina Campus offers a wide range of university certificate, diploma, and degree programs and maintains several unique programs relevant to First Nations studies and development.